In earlier versions, there was a dropdown in Tools | Options that let me choose whether or not I wanted to save files when building. It would be very useful to have this back. (VS2012 always saves when building.)

If you extended the Code-Folding ability to the horizontal axis as well, you fold on ( ) [ ] { } and maybe < > </ > for XML Literals.

Also extend to include, the Conditional Expression. (Note: [+] & [-] are representing the colwfold glyphs.
[+] IF myCondition Then
[-]Else
Rem ' Some Code Here]
End If
[-]If Cond Then
[-]ElseIf
[-][Else
End If

Or let the user arbitrarily highlight a block of code, to be folded.

Visual studio (and also SQL Management) "Find and Replace" dialog box could have button what switches values in "Find what" and "Replace with" fields.

You have nicely included the option to start debugging with different browsers. What really would complete an awesome debugging experience would be an option to define and select different resolutions and start debugging with a defined window size. Even the option to select multiple sizes and have several browser start with different resolutions would be nice.

In VS2008 Isolated Shell, the auto recover option is available. However, in VS2010 the auto recover is disabled (greyed out). Can you please re-enable this IDE feature for the Isolated Shell?

Allow users to 'sticky' comments /suggestions/prompts onto the design or code area and store them as meta info in the solution against that file.

These comments would be visually appealing.

These 'comments' could be toggled on and off allowing other users to see other developers intent.

These comments would not be contained in the design/code itself rather be held as meta data against lines/areas of that file.

In the RC (didn't try the beta),when you select a file in the Solution Explorer a preview pane opens with the content of the file. This feature is awesome but it doesn't work for parent files. Like if you have an App.xaml with a nested App.xaml.cs file file preview will only work for the nested App.xaml.cs file and not the parent App.xaml file. Please make it work for both.

When Visual Studio is compiling, show the progress (or at least Indeterminate progress) in the task bar, so if I work with another software in th mean time, I can no when the build is finished.

When Visual Studio trying quickly open selected file which have a size a lot of megabytes is done very slowly. Allow to set up maximum size of file for this feature.

Some of our solutions are rather large, so we like to keep projects organised with solution folders:

...\Service\...
...\Client\...
...\Install\...

Naturally, we want what we see in Solution Explorer, what we see on our disk, and what we see in source control to relate to each other. However, every time we create a new project, we have to remember to update the location. Even though I right click on Install, and say Add New Project, that new project appears at the root! (unless I specify **again** that I want it in Install).

I usually work with a laptop docked and 2 monitors and I have created a Visual Studio layout that use both monitors.

But it happens sometimes that I need to work in mobility and I have to remake the layout to fit one monitor.

It would be nice if I can save different layouts and load manually depending on the situations.

It would be nice if you could search and replace for a entire clock of code just like you can in dreamweaver.
and it would be a good idea if the search didn't so long to start when you search the entire solution.

If the Quick Preview Window shows the Designer, then it may load for a long time, or it may even crash the IDE (happens sometimes with our project).
At least add a Option to configure this behavior

This image describe how I have difficulties to read some highlighted words where I've a line with a diff